* Recent evidence indicate that PDE5 inhibition be associated vital excretion of deviant amounts of sodium within the urine.
Co-authors with Sherman are Lori J. Wirth, M.D., of the Dana-Farber Cancer Institute in Boston; Jean-Pierre Droz, M.D., of the Centre Leon Berard in Lyon, France; Michael Hofmann, M.D., Ph.D., of the Medical School Bern in Bern, Switzerland; Lars Bastholt, M.D., of Odense University Hospital in Odense, Denmark; Renato G. Martins, M.D., of the University of Washington in Seattle; Lisa Licitra, M.D., of the Istituto Nazionale dei Tumori in Milan, Italy; Michael J. Eschenberg, Yu-Nien Sun, Ph.D., Todd Juan, Ph.D., and Daniel E. Stepan, M.D., all of Amgen, Inc. in Thousand Oaks, Calif.; and Martin J. Schlumberger, M.D., of the Institut Gustave Roussy, University Paris Sud in Villejuif, France, on behalf of the Motesanib Thyroid Study Group.
"Studying the vasopressin receptor's mutation that affect urine concentration was a destiny to apprehend the role of every amino acids or run motif on this protein in cell physiology," run author Bouley said. "This acquaintance may be applied to other proteins and other diseases involving protein trafficking, with cystic fibrosis, where on dust abnormal proteins cut off in cell can't gross their mundane physiological manoeuvre," Bouley noted.
Source and allowance The study, qualified "Stimulation of AQP2membrane preliminary part in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra)," show up in the June precise of the American Journal of Physiology-Renal Physiology, published by the American Physiological Society. Research was conduct by Richard Bouley, Nuria Pastor-Soler, Ori Cohen, Margaret McLaughlin, Sylvie Breton and Dennis Brown at the Program in Membrane Biology and Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.
Research was support by graduate fellowship from the (U.S.) National Kidney Foundation and Kidney Foundation of Canada (Bouley) and several NIH grant (Brown, Breton and Pastor-Soler).
Editor's gen: A bootleg of the research paper by Bouley et al. is free to the environment. Members of the media may gain an electronic magazine and interview member of the research troop by interaction Mayer Resnick at the American Physiological Society, 301-634-7209, cell 301-332-4402 or APS Conference on NEUROHYPOPHYSEAL HORMONES, Vasopressin and Oxytocin: From Genomics and Physiology to Disease, and Therapy July 16-20, 2005, Steamboat Springs, Colorado The American Physiological Society was found in 1887 to foster foremost and applied bioscience. The Bethesda, Maryland-based society have high than 10,000 members and publish 14 peer-reviewed journal compose almost 4,000 article annually.
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